Month: 2025-06

TOKYO, June 3, 2025 - (JCN Newswire via SeaPRwire.com) - Anime Tokyo Station is an anime exhibition site focused on Japanese anime content, which has developed a devoted fan base around the world. It attracts 167,410 visitors (as of May 18, 2025), children and adults alike, from both Japan and overseas. We are pleased to announce the launch of the official Anime Tokyo Station YouTube channel, along with the release of a new promotional video narrated by renowned voice actor Akio Otsuka, introducing the facility.Promotional video narrated by Akio OtsukaAs you wander freely through the interior spaces of Anime Tokyo Station, you’ll encounter striking symbolic displays, special exhibitions that showcase the appeal of Japanese anime, archived materials, and a variety of services on each floor. Enjoy a leisurely tour of the facility with narration by renowned voice actor Akio Otsuka.Going forward, the official Anime Tokyo Station YouTube channel will regularly share new videos, including further introductions to the facility, as well as coverage of special exhibitions, workshops, and events. The channel aims to serve as a hub for anime exhibitions and keep viewers informed about Anime Tokyo Station’s ongoing initiatives.YouTube overviewChannel name: Anime Tokyo Station Official ChannelChannel URL: https://www.youtube.com/channel/UCSJOjGJE5Yiqw3PZ97AVdJwFacility Introduction Video: https://www.youtube.com/watch?v=1jp-OK_Kfe8Venue Overview- Name: Anime Tokyo Station (also known as "Anime Tokyo")- Location: Floors B1 to 2F of Tokyu East 5 (2-25-5 Minami-Ikebukuro, Toshima-ku, Tokyo)*4 minutes on foot from the East Exit of Ikebukuro Station- Hours: 11:00 a.m. to 7:00 p.m. (last admission: 6:45 p.m.)- Closed: Mondays*If Monday falls on a holiday, the venue will be open on Monday and closed on the following dayNew Year's holiday periodMay be closed on other daysPlease check the venue website before coming.- Admission fee: Free- Website: https://animetokyo.jp/en/ Inquiries regarding this press releasePublic Relations Office of "Anime Tokyo Station" (Kyodo PR)Contact person: Miri YasudaE-mail: animetokyo-pr@kyodo-pr.co.jpPress release: https://www.acnnewswire.com/docs/files/20250603.pdf Copyright 2025 JCN Newswire via SeaPRwire.com.

Strasbourg, France & Tokyo, Japan, June 2, 2025 - (JCN Newswire via SeaPRwire.com) - Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, and NEC Corporation (NEC; TSE: 6701), a leader in IT, network and AI technologies, have presented new positive data on TG4050 in a rapid oral presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting.These positive data confirm that individualized neoantigen therapeutic vaccine TG4050 is safe and feasible in the adjuvant setting of resectable HPV-negative locally advanced head and neck squamous cell carcinoma (HNSCC). TG4050 induces, as monotherapy, long-lasting immune responses to vaccine neoantigens sustained for up to 2 years, and these results met all trial endpoints (NCT04183166) including safety, feasibility, immune activation and disease-free survival (defined as survival without recurrence or death for any cause).TG4050 is based on Transgene’s myvac® platform and powered by NEC’s cutting-edge AI capabilities designed to optimize antigen selection.Positive data from Phase I, confirming proof of principle of Transgene’s viral vector based individualized cancer vaccine TG4050 in HPV-negative locally advanced head and neck cancer 100% disease free survival at a minimum of 2-year follow-up of treated patients (median follow-up: 30 months) in the Phase I part of the trial: all patients in the TG4050 treatment arm remain disease free while 3 patients in the observational arm have relapsed.Persistence of neoantigen-specific CD8+ T cell responses over 2 years after the start of TG4050 has been observed.Dr. Alessandro Riva, CEO of Transgene, commented: "The sustained clinical and immunogenicity outcomes observed over two years of TG4050 monotherapy, along with the positive safety profile, mark an important milestone for Transgene. These results reinforce both the clinical promise of TG4050 and our commitment to accelerate the development of this individualized immunotherapy in adjuvant setting for patients with HPV-negative, locally advanced head and neck cancer."Motoo Nishihara, Corporate EVP and CTO at NEC, commented: "This positive readout, combined with the durability of the efficacy data at two years, underscore the clinical potential of individualized cancer vaccine programs. It is a strong validation of our innovative AI platform and our dedication to advancing solutions that deliver meaningful, long-term value to patients and healthcare systems alike."Ongoing Phase II part of Phase I/II clinical trial of individualized neoantigen therapeutic cancer vaccine TG4050TG4050 is being evaluated in a randomized multicenter Phase I/II trial as a single agent in the adjuvant treatment of HPV-negative head and neck cancers (NCT04183166). Based on the promising data obtained in the Phase I part of the trial, Transgene and NEC extended the joint development of TG4050 in this indication with a Phase II extension of the trial.The Phase II part of the trial, aimed at confirming the encouraging results in a larger patient population and evaluating both immunological and clinical outcomes, is currently underway. All patients are expected to be randomized by Q4 2025. Altogether, the Phase I/II study will comprise approximately 80 patients.A conference call in English is scheduled June 6, 2025, at 3:00 p.m. CET. (9:00 a.m. ET)Webcast link to English language conference call: https://edge.media-server.com/mmc/p/x49uzc62 Please log in to the following link to obtain your personal telephone IDs: https://register-conf.media-server.com/register/BId8c981041ca84dad92bb2faa73fc5344 A replay of the call will be available on the Transgene website (www.transgene.com) following the live event.About TransgeneTransgene (Euronext: TNG) is a biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. The Company’s clinical-stage programs consist of a portfolio of viral vector-based immunotherapeutics. TG4050, the first individualized therapeutic vaccine based on the myvac® platform is the Company’s lead asset, with demonstrated proof of principle in patients in the adjuvant treatment of head and neck cancers. The portfolio also includes other viral-vector-based immunotherapies: TG4001 for the treatment of HPV-positive cancers, as well as BT-001 and TG6050, two oncolytic viruses based on the Invir.IO® viral backbone. The Company also conducts innovative discovery and preclinical work, aimed at developing novel viral vector-based modalities.With Transgene’s myvac® platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The myvac® approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.With its proprietary platform Invir.IO®, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses.Additional information about Transgene is available at: www.transgene.com Follow us on social media: X (formerly Twitter): @TransgeneSA — LinkedIn: @Transgene — Bluesky: @TransgeneAbout myvac®myvac® is a viral vector (MVA – Modified Vaccinia Ankara) based, individualized immunotherapy platform that has been developed by Transgene to target solid tumors. myvac®-derived products are designed to stimulate the patient’s immune system to recognize and destroy tumors using their own cancer specific genetic mutations. Transgene has set up an innovative network that combines bioengineering, digital transformation, established vectorization know-how and unique manufacturing capabilities. Transgene has been awarded "Investment for the Future" funding from Bpifrance for the development of its platform myvac®. TG4050 is the first myvac®-derived product being evaluated in clinical trials. Click here to watch a short video on myvac.About TG4050TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene’s myvac® technology and powered by NEC’s longstanding artificial intelligence (AI) and machine learning (ML) expertise. This virus-based therapeutic vaccine encodes neoantigens (patient-specific mutations) identified and selected by NEC’s Neoantigen Prediction System. The prediction system is based on more than two decades of expertise in AI and has been trained on proprietary data allowing it to accurately prioritize and select the most immunogenic sequences.TG4050 is designed to stimulate the immune system of patients in order to induce a T-cell response that is able to recognize and destroy tumor cells based on their own neoantigens. This individualized immunotherapy is developed and produced for each patient.About the Phase I/II clinical trialTG4050 is being evaluated in a Phase I/II clinical trial for patients with HPV-negative head and neck cancers (NCT04183166). An individualized treatment is created for each patient after they complete surgery and while they receive adjuvant therapy. Half of the participants received their vaccine immediately after completing adjuvant treatment. The other half were given TG4050 as an additional treatment at the time of recurrence of the disease as an additional treatment to standard of care (SoC). This randomized study is evaluating the treatment benefits of TG4050 in patients who are at risk of relapse. In the Phase I part, thirty-two evaluable patients have been included. The Phase II part is currently enrolling patients internationally.About NEC’s Neoantigen Prediction SystemNEC’s neoantigen prediction system utilizes its proprietary AI, such as graph-based relational learning, trained on multiple sources of biological data to discover candidate neoantigen targets. These targets are carefully analyzed using proprietary machine learning algorithms that include in-house HLA binding and antigen presentation AI tools to evaluate the likelihood of eliciting a robust and clinically relevant T-cell response. With NEC OncoImmunity now on board, NEC continues to strengthen its top-class neoantigen prediction pipelines with the aim of maximizing the therapeutic benefits of personalized cancer immunotherapy for patients worldwide.For more information, please visit NEC Bio at https://www.nec-bio.com or https://www.nec-bio.com/en_DD/research-and-innovation/our-approach/ About NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential.For more information, visit NEC at https://www.nec.com. DisclaimerThis press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company’s activities, perspectives, financial situation, results, regulatory authorities’ agreement with development phases, and development. The Company’s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company’s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors ("Facteurs de Risque") section of the Universal Registration Document, available on the AMF website (https://www.amf-france.org) or on Transgene’s website (www.transgene.fr). Forward-looking statements speak only as of the date on which they are made, and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future. Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, June 2, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. announced today the launch of “Pariet®S” (pharmaceutical requiring guidance), which is highly effective in alleviating severe heartburn andstomach pain caused by gastric acid reflux, at pharmacies and drugstores throughout Japan.(1)"Pariet S" is the first proton pump inhibitor (PPI(2)) to receive manufacturing and marketing approval as an over the counter (OTC) medicine in Japan. Rabeprazole sodium, in an amount equivalent to that used in the prescription product(3), works directly on the proton pumps that produce stomach acid, effectively alleviating severe heartburn caused by gastric acid reflux and stomach pain due to excessiveacid secretion. The medicine comes in small, easy-to-swallow tablets, with a once-daily dosage providing 24-hour relief.Rabeprazole sodium, the active ingredient in “Pariet S”, is a PPI developed at Eisai’s Tsukuba Research Laboratories. The medicine was first launched in Japan in 1997 as a prescription pharmaceutical underthe brand name “Pariet” and has since been approved more than 100 countries worldwide. It is widely prescribed to people struggling with acid-related disorders.In recent years, there is a tendency for increased stomach acid secretion due to disrupted eating habits, stress, and a decline in the infection rate of Helicobacter pylori. Moreover, the number of individuals experiencing gastric acid reflux has grown, driven by age-related weakening of the lower esophageal sphincter. Eisai will introduce “Pariet S” as a new treatment option in the OTC gastric medication market, aiming to alleviate sever heartburn and discomfort caused by gastric acid related conditions, and strongly support people in the daily living domain who wish for a comfortable and secure daily life.For further details, please refer to the product’s website for details about "Pariet S" (Japanese only) https://www.eisai.jp/products/pariet/pariets(1) "Pariet S" is classified as a drug that requires a pharmacist’s guidance at the time of sale(2) Proton Pump Inhibitor suppresses gastric acid secretion by inhibiting the “proton pump” which is the final step in the secretion process.(3) Contains rabeprazole10mg per tabletMedia Inquiries:Public Relations DepartmentEisai Co., Ltd.+81-(0)3-3817-5120 Copyright 2025 JCN Newswire via SeaPRwire.com.

TOKYO, June 2, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Corporation (“MC”) has agreed to acquire shares in DEScycle Ltd., a company known for its innovative technology in metal recovery from e-scrap. The two companies will also enter into a strategic business partnership to foster collaboration.E-scrap contains valuable materials such as copper and precious metals, and its value as an urban mine has grown in recent years. With the continued integration of AI into society, the rapid expansion of data centers is expected to increase the volume of e-scrap. However, due to the challenges of achieving clean and cost-effective recycling, a large portion of e-scrap is still disposed of in landfills, raising serious environmental concerns.DEScycle's proprietary technology* enables to selectively dissolve metals at room temperature and atmospheric pressure, and is expected recover metals with significantly lower energy consumption and environmental impact compared to conventional smelting methods. By effectively utilizing e-scrap as a secondary resource, it contributes to sustainable resource circulation.The funds raised by DEScycle will support the construction and operation of a pilot plant in the UK. Following the demonstration phase, a commercial-scale plant with an annual processing capacity of approximately 5,000 tons is scheduled to begin operations in the UK in 2028, with plans to further expand to North America, Japan, and other regions.MC will leverage its trading expertise and industry network to undertake marketing activities for metal products such as copper and precious metals derived from e-scrap using DEScycle's technology. Additionally, MC will utilize its investment expertise to explore the expansion of the business together with DEScycle, aiming to contribute to the realization of a circular economy.*Proprietary technology developed by DEScycle uses Deep Eutectic Solvents (DES) to selectively dissolve metals at room temperature and atmospheric pressure.DEScycleDEScycle is a deep technology company developing disruptive metals processing technologies utilising a novel and eco-friendly class of chemistry known as DES. DES are recyclable liquid salts that allow for low-temperature, low-energy operations; resulting in low-carbon, low-impact metals. DEScycle’s technology can end the reliance upon high-energy pollutive processes like smelting and the use of highly toxic chemicals in the metals industry.Initially focused on the $100bn e-waste market, DEScycle’s mission is to commercialise a clearly differentiated recycling technology with industry leading costs, performance, environmental impact and transparency.About Mitsubishi CorporationMitsubishi Corporation is a global integrated business enterprise that develops and operates business together with its offices and subsidiaries worldwide. MC has eight Business Groups that operate across virtually every industry: Environmental Energy, Material Solution, Mineral Resources, Urban Development and Infrastructure, Mobility, Food Industry, Smart-Life Creation, and Power Solution.Inquiry RecipientMitsubishi CorporationTelephone:+81-3-3210-2171 Copyright 2025 JCN Newswire via SeaPRwire.com.