Month: 2024-12

BAD HOMBURG, GERMANY, Dec 5, 2024 - (ACN Newswire via SeaPRwire.com) - Maxon, maker of powerful, approachable software solutions for content creators working in 2D and 3D design, motion graphics, visual effects, and more, today released updates across its Maxon One product suite, with new features in Cinema 4D, Redshift, ZBrush and ZBrush for iPad, and Red Giant. The release fulfills artists' holiday wishlists with new capabilities that enhance everyday workflows and improve quality of life for artists, animators, VFX professionals, and studios.Image courtesy of Patrick 4DWhether it's crafting unique models using brand new Cinema 4D Booleans that give cookie-cutter a whole new meaning or bringing a dazzling snowfall to life with Cinema 4D Particles, Maxon One makes it all possible. GoZ in ZBrush for iPad now makes it even easier to transfer creations from the comfort of your couch to the power of your PC or Mac, where the magic of ZBrush, Cinema 4D, Red Giant and Redshift bring those visions to life."From broadcast and film to branding, character creation to world-building, there is no corner of art and design that Maxon One tools do not touch, and with every new release, we aim to make the lives of creative professionals that much easier and more enjoyable - and what better time to bring the joy than the holidays?" said Philip Losch, CPTO of Maxon. "This update delivers improvements based on community input, from the powerful new Boolean workflows in Cinema 4D to cross platform workflows with ZBrush for iPad. Each enhancement inspires innovation across diverse creative fields that permeate through our everyday lives, whether that's on the screen, in the creation of consumer goods or architectural design, and even medical animation of world-changing ideas."Baking Holiday Magic With Patrick 4D3D artist and "Digital Chef" Patrick 4D, who specializes in digital photorealism for food and products, is teaming up with Maxon to bake up some digital goodies for the holiday season: a collection of gingerbread cookies crafted in ZBrush. Available now in the trial or full version of ZBrush, artists can make the cookies their own with tasty decorations and world building. To join in on the fun, share your creations with the Maxon community by tagging @maxonvfx on Instagram.Models That are Anything but Cookie-Cutter with Cinema 4DCinema 4D 2025.1 introduces a completely new Boolean generator that allows artists to easily create complex shapes from animated elements, streamlining the modeling process through intuitive shape addition and subtraction. This new algorithm is faster and more robust, enabling users to work with complex geometry while maintaining high frame rates, even with intricate animated booleans. The flexible user interface allows for the combination of multiple inputs and operations into a single boolean object, a significant upgrade from the previous limitation of just two inputs.In Cinema 4D, precise control over particle behavior is now possible with custom properties and the Particle Node Modifier, part of the growing GPU-accelerated Unified Simulation toolset, offering greater flexibility and creativity. Existing customers will appreciate quality-of-life improvements in Cinema 4D, including enhanced USD import/export and improvements to XRef performance and reliability for seamless collaboration. Interactive tutorials in the Learning Panel combine video guidance and UI highlights to simplify concepts and accelerate the learning process.Redshift Renders Really Fly With an AI Boost and Improved VisualizationRedshift combined with Cinema 4D and ZBrush are the ultimate building blocks for character and product design and architectural visualization, empowering creative professionals to craft breathtaking designs and models that transport clients to new dimensions. Redshift 2025.2 brings continued improvements to Toon rendering, even faster renders in ZBrush and Cinema 4D, and support for fully three-dimensional contours.Tightening of the Substance integrations gives users a fantastic workflow across Adobe and Maxon solutions (available as a bundle). Redshift Random Material Switch makes it easy to vary materials across MoGraph clones and other objects, while improved cross-platform AI-based denoising enables faster and more efficient renders.Creativity Unwrapped with ZBrush (for iPad)The cross-platform compatibility for ZBrush creations continues to see enhancements, with the ability to transfer with just a few clicks from iPad to desktop, where artists can refine, add animation and materials, and render. The complete workflow from concept to render starts the moment creativity strikes thanks to GoZ technology, and for the first time, artists can exchange creations bidirectionally between ZBrush for iPad and Cinema 4D. GoZ has also simplified the process of sending ZBrush sculpts to the 2025 versions of Maya and 3DSMAX.ZBrush desktop also now includes faster Redshift rendering, with denoising and separate AOV passes for shadows, reflections and more to more easily composite in Photoshop. The Anchor Brush in ZBrush for Desktop now has a new Bend mode, allowing users to easily pose characters using two anchor points.Additional updates to ZBrush for iPad, released in November, include UV and texture mapping, surface noise, localization, and improved support for Apple Pencil Pro. ZBrush for iPad includes nearly all the power of the full desktop application, and Maxon continues to close the gap with popular features to customize surfacing.Feeling Festive and On-Trend with Red Giant and Maxon StudioMaxon One's powerhouse for adding personal or branded flair to any project, Red Giant 2025.2 includes updates in Maxon Studio and Universe that make it easy for content creators to level up their videos with on-trend effects, transitions and motion templates. 2D Motion Designers and Compositors can get started easily with the help of Maxon Studio, an After Effects templating toolkit that offers hundreds of customizable graphics and effects, including a set of meticulously crafted Film Title templates. And, always on trend, Universe and Red Giant subscribers can now make use of six new Pixel Dither effects for effortless pixel art creation, using advanced dithering effects that capture the essence of retro gaming and animation.About MaxonMaxon makes powerful, yet approachable software solutions for content creators working in 2D and 3D design, motion graphics, visual effects and visualization. Maxon's innovative product portfolio helps artists supercharge their creative workflows. Our product lines include the award-winning Cinema 4D suite of 3D modeling, simulation and animation technology; the creativity-on-the-go Forger mobile sculpting app; the diverse Red Giant lineup of revolutionary editing, motion design and filmmaking tools; the leading-edge, blazingly fast Redshift renderer; and ZBrush, the industry-standard digital sculpting and painting solution.Press ContactMegan FasyGrithaus Agency(e) megan@grithaus.agency(p) +1 (617) 480-3674SOURCE: Maxon Computers Copyright 2024 ACN Newswire via SeaPRwire.com.

香港, 2024年12月4日 - (亞太商訊 via SeaPRwire.com) - 中信國際電訊集團有限公司（「中信國際電訊」，香港交易所股份代號：1883）全資擁有的中信國際電訊(信息技術) 有限公司(「中信國際電訊CPC」) 宣布勇奪三項業界大獎 ，肯定中信國際電訊CPC深耕網絡安全的卓越表現，表揚專業團隊深厚的行業知識與技術、員工高度的網絡安全意識及尖端的創新解決方案，以滿足市場對不斷增長的網絡安全需求 ，應對日益猖獗的網絡威脅和挑戰。 三項業界大獎包括:- 香港互聯網註冊管理有限公司(HKIRC)「共建員工防火牆」嘉許計劃2024 白金級獎 ；- Fortinet「2024年度最佳託管安全服務供應商」獎項 (Top MSSP of the Year 2024)；- Green Radar「2024 年度最佳企業業務合作夥伴」獎項 (Top Partner Enterprise Business FY24 )中信國際電訊 CPC 行政總裁黃政華先生表示：「該三項業界大獎展示我們對推動內部“員工防火牆”文化的承諾，同時透過我們的網絡安全專家團隊向企業客戶提供全面的解決方案，彰顯了我們內外實力的堅實基礎。業界對我們的肯定將激勵我們持續提升網絡安全創新方案，期望帶來更多的市場機遇，共同推動行業高質量發展。我們有信心，旗艦信息安全解決方案“TrustCSI™ 3.0雲網神盾” 在網絡安全市場保持領先優勢，鞏固我們作為前沿網絡安全領導者地位。」 HKIRC「共建員工防火牆」嘉許計劃香港互聯網註冊管理有限公司 (HKIRC) 與國際信息系統審計協會中國香港分會 (ISACA) 聯合舉辦的「共建員工防火牆」嘉許計劃圓滿舉行 ，參加機構涵蓋了銀行、物業管理、零售等行業的中小企及大型企業。該計劃旨在表彰得獎企業在過去一年內意識到網絡安全重要性並積極提升員工網絡安全意識的努力。「共建員工防火牆」嘉許計劃鼓勵更多機構採取積極的措施推廣「員工防火牆（Human Firewall）」理念 ，透過多種渠道如培訓、政策、溝通、演習等提高員工防護意識。最高級別白金級獎需要符合所有5項評審標準，包括網絡安全培訓 、網絡釣魚演習 、網絡安全政策 、通報渠道及網絡安全資訊傳遞 。中信國際電訊CPC 榮獲最高級別之白金級認證，表揚其過去不但致力在網絡安全技術上不斷提升、在系統和政策方面全面優化，並推出“TrustCSI™ 3.0 雲網神盾”資安服務，創新的服務框架，配備主動防禦技術以應對快速迭代的網絡威脅。 同時培養員工對網絡安全意識文化的決心，透過全球員工強度訓練及網絡安全演練，構建為公司的第二道防線，防範並能有效應對不斷變化的網絡威脅。 共創共贏，構建更堅固的防禦生態圈此外，中信國際電訊CPC 再次榮獲兩家網絡安全服務生態圈夥伴Fortinet及Green Radar頒發多個卓越獎項，彰顯其在全球性合作策略和網絡安全領域高質量的協同效益與服務能力，透過持續的技術創新和與生態圈夥伴的緊密合作，中信國際電訊CPC得以不斷提升産品和服務質量，以滿足市場對網絡安全方案的需求，並超越競爭對手。其中包括在 2023 年推出的 TrustCSI™ 3.0 雲網神盾，通過智能技術重塑安全運營中心（SOC）的核心服務能力，為企業提供主動式防禦，將AI 應用融入其業務中，優化智能營運。首先， Fortinet頒發的「2024 年度最佳託管安全服務供應商」獎項肯定了中信國際電訊CPC 前沿的託管安全服務，超越業界標準。另外，Green Radar「2024 年度最佳企業業務合作夥伴」獎項表揚中信國際電訊CPC與合作夥伴携手推動創新解决方案，以滿足企業客戶獨特的網絡安全需求。積極提升內外網絡安全及創新技術中信國際電訊CPC無論對內或對外，一直積極展現卓越的網絡安全能力。在對內方面，中信國際電訊CPC致力培育員工網絡安全意識，而員工在工作上時刻保持警惕和採用主動的防禦措施，體現了對網絡安全的最佳實踐，保護公司的數碼資產。在對外方面，中信國際電訊CPC致力成為企業可信賴的TechOps 信息安全賦能者，旗下的網絡安全專家團隊具備前瞻思維和追求卓越成就的精神，透過專業服務和創新定製的解決方案，助力客戶輕鬆及靈活地應對瞬息萬變的數碼環境。秉持“創新不斷”服務理念，中信國際電訊CPC持續將人工智能技術整合到信息安全產品組合中，提供先進網絡安全解決方案以應對越發猖獗的網絡威脅。中信國際電訊CPC最新的TrustCSI™ AI滲透測試(AI Pentest)服務如同網絡AI掃地機器人，24x7全自動化工作，協助企業找出網絡中的致命漏洞，建立強大的防禦機制 。為了強化企業客戶內外部的漏洞保護，中信國際電訊CPC特別提供了一個最新內外評估組合方案，協助客戶通過對內的AI滲透測試服務，同時，進行攻擊面管理 (Attack Surface Management)，增強公司對外部漏洞的抵禦能力，並有系統地優化漏洞識別、排列漏洞優次、補救和持續監控等攻擊，透過多管齊下的防護措施降低潛在的網絡攻擊風險，提升企業安全管理策略。詳情可瀏覽 https://www1.citictel-cpc.com/promotion/2411XmasOffer/index-TC.html中信國際電訊CPC簡介中信國際電訊（信息技術）有限公司（「中信國際電訊CPC」）是中信國際電訊集團有限公司（香港交易所股份代號：1883）的全資附屬公司，一直矢志透過先進技術及旗艦解決方案，包括TrueCONNECT™專用網絡服務、TrustCSI™信息安全解決方案、DataHOUSE™全球統一雲數據中心解決方案及SmartCLOUD™雲端運算解決方案，為全球跨國企業提供綜合數碼解決方案， 滿足不同行業的ICT服務需求。憑借「創新‧不斷」的服務理念，中信國際電訊CPC積極利用創新技術，提煉“技術賦能”，將人工智能、擴增實境、大數據、物聯網和其他尖端新興技術，融合深度學習及智能數據分析技術，轉化為“數據賦能”生成式AI+應用，重塑企業智能營運之旅。中信國際電訊CPC以「服務在地，連接全球」的優勢，承諾為客戶提供最優質的一站式ICT服務。全球化網絡資源連接近170個服務據點、60多個SDWAN 網關；21個雲服務中心、30多個數據中心及3個全天候運作的安全運作中心，服務遍布约160個國家和地區，無縫連接亞洲、歐美、非洲、中東以及中亞等地區 。透過全球化服務佈局，多年不斷深耕各個行業與領域經驗，一系列國際認證（SD-WAN Ready, ISO 9001、14001、20000、27001 及27017），確保為企業提供國際化標準及專業在地服務能力，成為客戶信賴的信息智能化服務供應商。請瀏覽 www.citictel-cpc.com 獲取更多資訊。傳媒查詢：Catherine Yuen中信國際電訊CPC(852) 2170 7536電郵：catherine.yuen@citictel-cpc.com Copyright 2024 亞太商訊 via SeaPRwire.com.

SINGAPORE, Dec 4, 2024 - (ACN Newswire via SeaPRwire.com) - How much sugar does a Singaporean typically take in a day? In a recent speech by Health Minister Mr. Ong Ye Kung, Singapore is too sweet. While the average daily sugar intake of Singaporeans has fallen from 60g in 2018 to 56g in 2022, this number still works out to about 11 teaspoons of daily sugar consumption, about 10% higher than the ideal intake of less than 50g.Amid an ageing population, the younger generation in Singapore is also increasingly affected by this chronic condition, highlighting a growing national health concern related to sugar consumption.Sugar, a common mis-solution to anxiety, often provides a sense of fleeting comfort. The instant boost in dopamine from sugar can create a cycle of dependency, giving temporary relief from stress or anxiety but contributing to harmful physical effects, such as inflammation, weight gain, and insulin resistance.The overconsumption of sugar, combined with sedentary lifestyles and other unhealthy dietary habits have contributed to diabetes becoming a major global health crisis today – Alarmingly, diabetes rates are rising among the younger generation, including both teenagers and young adults, contributing to nearly half a million cases in Singapore. Astonishingly, 40% of Singaporeans remain unaware of their pre-diabetic status, an often silent condition that could lead to type 2 diabetes.Diabetes is a chronic condition that if left unmanaged, can lead to serious health complications, including an increased risk of cardiovascular disease, kidney failure, nerve damage or even vision loss. However, type 2 diabetes can be prevented through proactive lifestyle changes, including healthy eating, regular physical activity, so as to maintain optimal blood sugar levels.In line with World Diabetes Day on 14 November, LAC (pronounced as L-A-C) is dedicated to highlight the importance of taking preventative measures against diabetes. By incorporating supplements that support blood sugar regulation and reduce carbohydrate absorption, along with a healthy diet and increased physical activity, individuals can maintain their glucose levels and maintain their metabolic health.LAC GlucoX is designed to support healthy glucose levels. Formulated with bitter melon and Fibersol-2, Banaba leaf, Gymnema, Chromium and Brown Seaweed, GlucoX helps slow down carbohydrate absorption and optimises glucose utilisation, supporting individuals in managing their blood sugar levels effectively.LAC Bitter Melon Formula, is formulated with Momordica Charantia Polysaccharide (MCP), a key compound from bitter melon known for its ability to support healthy blood glucose levels. It enhances the body’s ability to regulate insulin production and supports the overall metabolic health of individuals. Copyright 2024 ACN Newswire via SeaPRwire.com.

SAN FRANCISCO, CA & MUMBAI, Dec 2, 2024 - (ACN Newswire via SeaPRwire.com) - CleverTap, the all-in-one engagement platform, has released its market research report on “The State of App and Web User Experience Optimization”. The report sheds light on how digital-first brands are leveraging experimentation and personalization on their apps and websites to drive customer engagement and business growth. It also highlights roadblocks faced by marketers and product managers while experimenting with the UI, workflows, and functionality across apps and websites.For a thorough understanding of the current landscape, this report draws insights from a diverse group of respondents – with data gathered through structured surveys and in-depth interviews – representing organizations with over two million customers across 50+ countries. This includes VPs, CMOs, and product managers ranging from startups to large enterprises across various industries. – Together, they offer valuable insights into how businesses optimize app and web experiences to drive customer engagement and business growth.While 95% of surveyed product managers and 88% of marketers believe that the right user experience is essential for driving customer engagement and retention — many report significant challenges to effectively experimenting with app and web user experiences. Despite recognizing its importance, they reported difficulties such as limited resources, data gaps, and technical constraints that hinder their ability to innovate and deliver impactful user experiences. Other notable findings from the report include -81.9% of product managers rarely experiment with their app and web experiences before making changes to them. The top challenges quoted include lack of resources (46%), inadequate data and analytics (31%), and technical issues (19%)54% of product managers are unable to support marketers in experimenting with onboarding flows, banner placement, homepage content and other similar app and web experiences.81% of marketers believe it would make a significant impact if they could independently experiment with multiple variations of web and app experiences within a no-code framework provided by their product management function.Commenting on the report, Jacob Joseph, Vice President - Data Science, CleverTap said, “With consumer expectations constantly rising, brands need to go beyond perfecting their channel strategies and also focus on enhancing the in-app and web experiences to drive results from their marketing efforts. Since all channels ultimately lead users to the app or website, an unsatisfactory experience there can render all your efforts ineffective and become a missed opportunity. Personalization and experimentation on apps and websites are critical to reducing churn and driving growth, yet resource constraints and data gaps hinder marketers and product managers. We are committed to helping businesses navigate these challenges with CleverTap’s Product Experiences, which offers effortless ways to personalize and experiment with app and web experiences driving stronger engagement and lasting brand loyalty."For more information and insights download the report here. About CleverTapCleverTap is the leading all-in-one customer engagement platform that helps brands unlock limitless customer lifetime value. CleverTap is trusted by over 2000 brands like Decathlon, Domino’s, Levis, Jio, Emirates NBD, Puma, Croma (A Tata Enterprise), Swiggy, SonyLIV, Axis Bank, AirAsia, TD Bank, Ooredoo, and Tesco to help build personalized experiences for all their customers. The platform is powered by TesseractDB™ – the world’s first purpose-built database for customer engagement, offering speed and cost efficiency at scale.Backed by top-tier investors such as Accel, Peak XV Partners, Tiger Global, CDPQ and 360 One, the company is headquartered in San Francisco, with presence across Seattle, London, São Paulo, Bogota, Mexico, Amsterdam, Sofia, Dubai, Mumbai, Bangalore, Singapore, Vietnam, and Jakarta.For more information, visit clevertap.com or follow us on:LinkedIn: https://www.linkedin.com/company/clevertap/ X: https://twitter.com/CleverTap Forward-Looking StatementsSome of the statements in this press release may represent CleverTap's belief in connection with future events and may be forward-looking statements, or statements of future expectations based on currently available information. CleverTap cautions that such statements are naturally subject to risks and uncertainties that could result in the actual outcome being absolutely different from the results anticipated by the statements mentioned in the press release.Factors such as the development of general economic conditions affecting our business, future market conditions, our ability to maintain cost advantages, uncertainty with respect to earnings, corporate actions, client concentration, reduced demand, liability or damages in our service contracts, unusual catastrophic loss events, war, political instability, changes in government policies or laws, legal restrictions impacting our business, impact of pandemic, epidemic, any natural calamity and other factors that are naturally beyond our control, changes in the capital markets and other circumstances may cause the actual events or results to be materially different, from those anticipated by such statements. CleverTap does not make any representation or warranty, express or implied, as to the accuracy, completeness, or updated or revised status of such statements. Therefore, in no case whatsoever will CleverTap and its affiliate companies be liable to anyone for any decision made or action taken in conjunction.For more information:SONY SHETTYDirector, Communications, CleverTap+91 9820900036sony@clevertap.comASHMIT CHAUDHARYAssociate Consultant, Archetype+91 8850752121ashmit.chaudhary@archetype.co Copyright 2024 ACN Newswire via SeaPRwire.com.

- Patients in the low-dose cohort who have completed 36 weeks of treatment, 9 out of 11 (81.8%) achieved overall clinical remission and 10 out of 11 (91%) achieved immunological complete remission.- In the high dose cohort, 6 out of 7 (85.7%) patients achieved overall clinical remission and all patients achieved immunological complete remission by week 24.- EVER001 was generally safe and well tolerated. No clinically significant adverse events typically associated with earlier-generation BTK inhibitors, such as bleeding, arrhythmia, severe infection, leukopenia, thrombocytopenia, or severe liver function impairment, were reported.SHANGHAI, Dec 4, 2024 - (ACN Newswire via SeaPRwire.com) - Everest Medicines (HKEX 1952.HK,“Everest”, or the "Company"), a biopharmaceutical company focused on the discovery, clinical development, manufacturing and commercialization of innovative therapeutics, today announced positive results in the ongoing Phase 1b/2a clinical trial for the treatment of primary membranous nephropathy (pMN) with EVER001 (previously known as XNW1011), a next-generation covalent reversible Bruton's tyrosine kinase (BTK) inhibitor. In an analysis of the data available as of September 13th, 2024, results from the Phase 1b/2a clinical trial showed that for patients in the low-dose cohort who have completed 36 weeks of treatment, 9 out of 11 (81.8%) achieved overall clinical remission1 and 10 out of 11 (91%) achieved immunological complete remission (ICR)2. In the high dose cohort, 6 out of 7 (85.7%) patients achieved overall clinical remission and all patients achieved ICR by week 24.EVER001 is a covalent reversible BTK inhibitor with potentially best-in-class characteristics for the treatment of autoimmune renal diseases. Compared to covalent irreversible BTK inhibitors, EVER001 offers improved selectivity while maintaining high potency, thereby potentially avoiding many of the side effects associated with earlier-generation BTK inhibitors. Everest Medicines holds global rights to EVER001 for the treatment of renal diseases.The Phase 1b/2a clinical trial of EVER001 for the treatment of pMN is an ongoing trial conducted in China. A total of 31 patients with biopsy-proven pMN who tested positive for anti-PLA2R autoantibodies were enrolled into two cohorts. The total treatment duration was 36 weeks. Based on the patient data collected by September 13th, 2024, in the low-dose cohort, the geometric least squares mean 24-hour proteinuria decreased by 78.3% at week 36 compared to baseline, while the high-dose cohort achieved a 73.8% reduction by week 24. EVER001 treatment induced greater than 90% reductions in anti-PLA2R antibody as early as week 24 in the low-dose cohort and week 12 in the high-dose cohort. EVER001 was generally safe and well tolerated. No clinically significant adverse events typically associated with earlier-generation BTK inhibitors, such as bleeding, arrhythmia, severe infection, leukopenia, thrombocytopenia, or severe liver function impairment, were reported."We are excited to see the encouraging results in this preliminary analysis of our Phase 1b/2a clinical proof-of-concept trial of EVER001. This demonstrates the potential of EVER001 as a next-generation BTK inhibitor for the treatment of various autoimmune renal diseases, including pMN. "Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines, said："This data release marks the first time Everest Medicines has disclosed results from its global pipeline. We look forward to completing this trial and sharing detailed data in future conferences and publications. Moving forward, we will continue to drive the global clinical development of EVER001, to meet patients' urgent clinical needs.”Membranous nephropathy is a common pathological type of nephrotic syndrome in adults, and its prevalence in China has been increasing, ranking second only to IgA nephropathy3. There are about 2 million patients with pMN in China, with an estimated 80,000 to 100,000 patients in the United States, 80,000 in Europe, and 40,000 in Japan. There are no approved drugs for this indication worldwide. The current treatment goal is to improve remission rates, reduce high relapse rates, and minimize the risk of chronic toxicity caused by currently available treatments. More than one-third of pMN patients still progress to end-stage renal disease under current standards of care.This Phase 1b/2a clinical trial was approved by the Center for Drug Evaluation of the National Medical Products Administration in September 2022 to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of EVER001 in Chinese patients with glomerular diseases characterized by proteinuria. The previously published results of a Phase 1 study conducted in healthy Chinese and Australian subjects conducted by SinoMab BioScience indicate that EVER001 has high selectivity, excellent pharmacokinetic properties, a good safety profile, and strong target binding.About EVER001EVER001 (previously known as XNW1011) is a next-generation covalent reversible Bruton's tyrosine kinase (BTK) inhibitor in development globally for the treatment of renal diseases. BTK is an essential component of the B-cell receptor signaling pathways that regulate the survival, activation, proliferation, and differentiation of B lymphocytes. Targeting BTK with small molecule inhibitors has been demonstrated to be an effective treatment option for B-cell lymphomas and autoimmune diseases. Based in part on results from a completed phase 1 trial with healthy subjects conducted by SinoMab in China, EVER001 exhibited high selectivity, excellent pharmacokinetics properties, strong target binding and a safety profile that supports continued clinical development.Under an exclusive licensing agreement with Sinovent Pharmaceuticals and SinoMab BioScience, Everest owns global rights to develop, produce and commercialize EVER001 for the treatment of renal diseases.Investor Calls InformationEverest Medicines will hold investor calls on the data results from EVER001 Phase 1b/2a clinical study in primary membranous nephropathy. EVER001 is a next-generation covalent reversible Bruton’s tyrosine kinase (BTK) inhibitor, and Everest owns the global rights to develop EVER001 for the treatment of renal diseases.The English session of the conference call will be held at 9:00 AM on Dec. 4, 2024, Beijing Time (8:00 PM U.S. Eastern Time on Dec. 3, 2024) and the Mandarin session of the conference call will be held at 10:30 AM Beijing Time on the same day (9:30 PM U.S. Eastern Time on Dec. 3, 2024).The conference calls can be accessed by the following links:For English Session:Time: 9:00 AM Beijing Time, Wednesday, Dec. 4, 2024 (8:00 PM U.S. Eastern Time on Dec. 3, 2024)Pre-Registration Link: https://www.acecamptech.com/eventDetail/60510700Webcast Link:https://www.acecamptech.com/meeting_live/70512679/774680?event_id=60510700Alternatively, participants may dial in to the conference call using below dial-in information:United States: +1-646-2543594 (EN)Chinese Mainland: +86-10-58084166 (EN), +86-10-58084199 (CN)Hong Kong, China: +852-30051313 (EN), +852-30051355 (CN)United Kingdom: +44-12-1368-0466 (EN)International: +1-866-6363243 (EN)Password: 842080For Mandarin Session:Time: 10:30 AM Beijing Time, Wednesday, Dec. 4, 2024 (9:30 PM U.S. Eastern Time on Dec. 3, 2024)Webcast Link: https://s.comein.cn/n3arj55sAlternatively, participants may dial into the conference call using below dial-in information:United States: +1-646-3578788, +1-408-7093255Chinese Mainland: 400-969-8928, 400-806-3263Hong Kong, China: +852-301-83602Taiwan, China: +886-226563394, +886-277417882Singapore: +65-64075649, +65-66220840United Kingdom: +44-2070970018 International: +86-2362737123Password: 377570The replay of English session will be available shortly after the call and can be accessed by visiting the Company’s website at http://www.everestmedicines.com.About Everest MedicinesEverest Medicines is a biopharmaceutical company focused on discovering, developing, manufacturing and commercializing transformative pharmaceutical products and vaccines that address critical unmet medical needs for patients in Asian markets. The management team of Everest Medicines has deep expertise and an extensive track record from both leading global pharmaceutical companies and local Chinese pharmaceutical companies in high-quality discovery, clinical development, regulatory affairs, CMC, business development and operations. Everest Medicines has built a portfolio of potentially global first-in-class or best-in-class molecules in the company’s core therapeutic areas of renal diseases, infectious diseases and autoimmune disorders. For more information, please visit its website at www.everestmedicines.com.Forward-Looking Statements:This news release may make statements that constitute forward-looking statements, including descriptions regarding the intent, belief or current expectations of the Company or its officers with respect to the business operations and financial condition of the Company, which can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “confident” and similar statements. Such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, or other factors, some of which are beyond the control of the Company and are unforeseeable. Therefore, the actual results may differ from those in the forward-looking statements as a result of various factors and assumptions, such as future changes and developments in our business, competitive environment, political, economic, legal and social conditions. The Company or any of its affiliates, directors, officers, advisors or representatives has no obligation and does not undertake to revise forward-looking statements to reflect new information, future events or circumstances after the date of this news release, except as required by law.References:1.Overall clinical remission (complete remission or partial remission): 24h proteinuria complete remission (CR): 24h proteinuria < 0.3g/24 h; 24h proteinuria partial remission (PR): 24h proteinuria < 3.5g/24h, but ≥0.3g/24 h, and reduction > 50%, regardless of eGFR or the serum albumin level from baseline.2. Immunological complete remission (ICR): anti-PLA2R titer < 20RU/ml (negative).3. Expert consensus on the application of rituximab in the treatment of membranous nephropathy, Chin J Intern Med, March 2022, Vol. 61, No. 3. Copyright 2024 ACN Newswire via SeaPRwire.com.

- 在已完成36周治療的低劑量組患者中，81.8%（9/11）的患者實現臨床緩解，高劑量組中已完成24周治療的患者已有85.7%（6/7）實現臨床緩解。- 除低劑量組的1例患者外，其他所有完成36周治療的低劑量組患者，以及所有經24周治療的高劑量組患者分別在36周和24周都實現了免疫學完全緩解。- EVER001總體安全性和耐受性良好。未見在其他共價非可逆BTK抑制劑上觀察到的有臨床意義的不良事件，如出血、心律失常、嚴重感染、白細胞減少、血小板減少、嚴重肝功能損傷等。上海, 2024年12月4日 - (亞太商訊 via SeaPRwire.com) - 雲頂新耀（HKEX 1952.HK）是一家專注于創新藥研發、臨床開發、製造和商業化的生物製藥公司，今日宣佈新一代共價可逆布魯頓酪氨酸激酶（BTK）抑制劑EVER001膠囊（又名：XNW1011）在治療原發性膜性腎病（primary membranous nephropathy，pMN）的1b/2a期臨床試驗階段性資料取得積極結果。直至9月13日的資料截止日期，結果顯示，在已完成36周治療的低劑量組患者中，81.8%（9/11）的患者實現臨床緩解，高劑量組中已完成24周治療的患者已有85.7%（6/7）實現臨床緩解。除低劑量組的1例患者外，其他所有完成36周治療的低劑量組患者，以及所有經24周治療的高劑量組患者分別在36周和24周都實現了免疫學完全緩解。EVER001是一款適用於自身免疫性腎臟疾病的共價可逆BTK抑制劑。與共價不可逆BTK抑制劑相比，EVER001作為一款潛在的同類最佳產品，在保持高活性的同時具有高選擇性，避免持續抑制帶來的毒副作用。雲頂新耀擁有這款產品用於腎病治療的全球權益。EVER001治療原發性膜性腎病的1b/2a期臨床試驗為一項正在進行中的中國研究。共有31名經腎臟活檢證實的抗-PLA2R自身抗體陽性的原發性膜性腎病患者分別入組低劑量組和高劑量組，接受EVER001共36周的治療。截至2024年9月13日的資料分析，低劑量組的24小時蛋白尿幾何平均值（最小二乘法）在36周相較於基線下降78.3%，而高劑量組在24周即出現73.8%的下降。抗-PLA2R自身抗體水準在資料截止日期時已達到接近100%的下降，而早在低劑量組的24周和高劑量組的12周，抗-PLA2R自身抗體下降已超過90%。EVER001總體安全性和耐受性良好。未見在其他共價非可逆BTK抑制劑上觀察到的有臨床意義的不良事件，如出血、心律失常、嚴重感染、白細胞減少、血小板減少、嚴重肝功能損傷等。雲頂新耀首席執行官羅永慶表示：「非常高興看到EVER001在此次公佈的階段性資料中取得了積極的結果。這顯示了EVER001作為新一代BTK抑制劑，對包括原發性膜性腎病在內的多種自身免疫性腎病治療的巨大潛力。迄今為止，全球沒有獲批原發性膜性腎病適應症的藥物。作為首個公佈的具有全球權益的管線產品資料，EVER001在原發性膜性腎病患者中取得的階段性結果令人鼓舞。我們也期待該1b/2a期臨床試驗的完成及更多相關資料的發表。我們將繼續推進EVER001的全球臨床開發，以最快速度滿足患者的臨床需求。」膜性腎病為成人腎病綜合征常見的病理類型，在我國的患病率呈逐年升高的趨勢，是發病率僅次於IgA腎病的原發性腎小球腎炎1。我國目前有約200萬原發性膜性腎病患者，而在美國約有8萬-10萬患者，歐洲約8萬患者，日本約4萬患者。目前全球沒有獲批此適應症的藥物。超過1/3的原發性膜性腎病患者最終將進展為終末期腎病，全球亟需研發能提高治療緩解率、降低高復發率、減少慢性腎毒性風險的治療藥物。此項1b/2a期臨床試驗於2022年9月獲得中國國家藥品監督管理局藥品審評中心批准，用於評價EVER001在蛋白尿為特徵的腎小球疾病的中國患者中的安全性、療效、藥代動力學和藥效學。此前公佈的中國抗體製藥在中國健康受試者中進行的1期研究結果表明，EVER001具有高選擇性、優異的藥代動力學特徵、良好的安全性特徵以及強大的靶點結合力。關於EVER001EVER001膠囊（又名：XNW1011）是新一代共價可逆的布魯頓酪氨酸激酶（BTK）抑制劑，正在全球範圍內開發用於治療腎病。BTK是B細胞受體信號通路的重要組成部分，可調節B淋巴細胞的存活、啟動、增殖和分化。應用小分子抑制劑靶向BTK是治療B細胞淋巴瘤和自身免疫性疾病的有效選擇。中國抗體製藥在國內完成的健康受試者I期研究結果表明，EVER001具有高選擇性、優異的藥代動力學特徵、強大靶點結合力和良好的安全性特徵，研究結果支援其進一步臨床開發。根據與信諾維醫藥和中國抗體製藥的獨家授權合約，雲頂新耀擁有在全球開發、生產和商業化EVER001用於治療腎病的權利。投資人會議公司將舉行中英文投資人線上會議，公佈新一代共價可逆布魯頓酪氨酸激酶（BTK）抑制劑 EVER001膠囊治療原發性膜性腎病的1b/2a期臨床試驗資料。雲頂新耀擁有EVER001在全球範圍內開發用於治療腎病領域的權益。英文場次將於北京時間2024年12月4日上午9時（美國東部時間12月3日晚上8時）舉行；中文場次將於北京時間同日上午10:30時（美國東部時間12月3日晚上9:30時）舉行。英文會議：會議時間：北京時間2024年12月4日，星期三，上午9時（美國東部時間12月3日晚上8時）提前註冊連結：https://www.acecamptech.com/eventDetail/60510700會議直播連結：https://www.acecamptech.com/meeting_live/70512679/774680?event_id=60510700同時，參會者也可以使用以下撥入資訊撥入電話會議：美國：+1-646-2543594 (EN)中國大陸：+86-10-58084166 (EN)，+86-10-58084199 (CN)中國香港：+852-30051313 (EN)，+852-30051355 (CN)英國：+44-12-1368-0466 (EN)國際：+1-866-6363243 (EN)會議代碼：842080中文會議：會議時間：北京時間2024年12月4日，星期三，上午10:30時（美國東部時間12月3日晚上9:30時）會議直播連結：https://s.comein.cn/n3arj55s同時，參會者也可以使用以下撥入資訊撥入電話會議：美國:+1-646-3578788，+1-408-7093255中國大陸:400-969-8928，400-806-3263中國香港:+852-301-83602中國台灣:+886-226563394，+886-277417882新加坡:+65-64075649，+65-66220840英國:+44-2070970018海外:+86-2362737123會議密碼:377570英文會議結束後，您可以通過訪問雲頂新耀官網（http://www.everestmedicines.com）收聽英文會議重播。關於雲頂新耀雲頂新耀是一家專注于創新藥和疫苗研發、臨床開發、製造和商業化的生物製藥公司，致力於滿足亞洲市場尚未滿足的醫療需求。雲頂新耀的管理團隊在中國及全球領先製藥企業從事過高品質研發、臨床開發、藥政事務、化學製造與控制（CMC）、業務發展和商業化運營，擁有深厚的專長和豐富的經驗。雲頂新耀已打造多款疾病首創或者同類最佳的藥物組合，公司的治療領域包括腎科疾病、感染性和傳染性疾病、自身免疫性疾病。有關更多資訊，請訪問公司網站：www.everestmedicines.com。前瞻性聲明本新聞稿所發佈的信息中可能會包含某些前瞻性表述，乃基於本公司或管理層在做出表述時對公司業務運營情況及財務狀況的現有看法、相信、和現有預期，可能會使用「將」、「預期」、「預測」、「期望」、「打算」、「計畫」、「相信」、「預估」、「確信」及其他類似詞語進行表述。這些前瞻性表述並非對未來業績的保證，會受到風險、不確定性及其他因素的影響，有些乃超出本公司的控制範圍，難以預計。因此，受我們的業務、競爭環境、政治、經濟、法律和社會情況的未來變化及發展等各種因素及假設的影響，實際結果可能會與前瞻性表述所含資料有較大差別。本公司及各附屬公司、各位董事、管理人員、顧問及代理未曾且概不承擔更新該稿件所載前瞻性表述以反映在本新聞稿發布日後最新信息、未來項目或情形的任何義務，除非法律要求。參考文獻：1.利妥昔單抗在膜性腎病中應用的專家共識，中華內科雜誌2022年3月第61卷第3期 Copyright 2024 亞太商訊 via SeaPRwire.com.

TSUKUBA, Japan, Dec 2, 2024 - (ACN Newswire via SeaPRwire.com) - Polymers, such as plastics, are essential in many aspects of life and industry, from packaging and cars to medical devices and optic fibres. Their value comes from diverse properties that are largely determined by their monomers – the single chemical units – that make up a polymer. Unfortunately, it can be challenging to control the chemical behaviour of monomers during manufacture to achieve a desired outcome.The flow synthesis reactor with two bottles containing a monomer, initiator and solvent mixed using a micromixer. The synthesis is controlled with AI-based design of experimental conditions such as the temperature and a flow rate. Now, a team of researchers led by Professor Mikiya Fujii of the Nara Institute of Science and Technology in Japan have used machine learning to mathematically model the polymerization process and reduce the need for time-consuming and expensive experimentation. Their results have been published in the journal Science and Technology of Advanced Materials: Methods.Machine learning algorithms need data, so the researchers designed a polymerization process that would quickly and efficiently generate experimental data to feed into the mathematical model. The target molecule was a styrene-methyl methacrylate co-polymer, which was made by mixing styrene and methyl methacrylate monomers, both already dissolved in a solvent with an added initiator substance, then heating them in a water bath.The team also used a method called flow synthesis, in which the two monomer solutions are mixed and heated in a constant flow. This allows for better mixing, more efficient heating, and more precise control of heating time and flow rate, which makes it ideal for use with machine learning.The modelling evaluated the effect of five key variables in the polymerization process: the concentration of the initiator, the ratio of solvent to monomer, the proportion of styrene, the temperature of the reaction, and the time spent in the water bath. The goal was to have an end product with as close to 50% styrene as possible.Once enough experimental data was available, the machine learning process took only five cycles of calculation to achieve the ideal proportion of styrene to methyl methacrylate. The results showed that the key was a lower temperature and longer time in the water bath, as well as lowering the relative concentration of the monomer in the solvent. The researchers were surprised to discover that the solvent concentration was just as important as the proportion of monomers going into the mix.“Our results demonstrate that machine learning not only can explicitly reveal what humans may have implicitly taken for granted but can also provide new insights that weren’t recognized before,” Professor Mikiya Fujii says. “The use of machine learning in chemistry could open the door for smarter, greener manufacturing processes with reduced waste and energy consumption.”Further informationMikiya FujiiNara Institute of Science and TechnologyEmail: fujii.mikiya@ms.naist.jp Paper: https://doi.org/10.1080/27660400.2024.2425178About Science and Technology of Advanced Materials: Methods (STAM-M)STAM Methods is an open access sister journal of Science and Technology of Advanced Materials (STAM), and focuses on emergent methods and tools for improving and/or accelerating materials developments, such as methodology, apparatus, instrumentation, modeling, high-through put data collection, materials/process informatics, databases, and programming. https://www.tandfonline.com/STAM-M Dr Yasufumi NakamichiSTAM Publishing DirectorEmail: NAKAMICHI.Yasufumi@nims.go.jp Press release distributed by Asia Research News for Science and Technology of Advanced Materials. Copyright 2024 ACN Newswire via SeaPRwire.com.

SINGAPORE, Dec 4, 2024 - (ACN Newswire via SeaPRwire.com) - OKX, the leading cryptocurrency exchange, has partnered with DeAgentAI, the first AI-driven feedback incentive protocol in Web3, to launch an exclusive airdrop campaign. Starting December 3rd, users can complete simple tasks on OKX Wallet to win a share of $50,000 worth of DA tokens.Click here to join the campaign: https://www.okx.com/web3/giveawayParticipating in the DeAgentAI and OKX Wallet airdrop is easy. Download the OKX Wallet, follow DeAgentAI social media networks, and complete a few simple tasks such as sharing campaign posts, and you can claim your rewards. The campaign runs from December 3rd for two weeks-don't miss out!This collaboration brings users unparalleled opportunities to explore advanced AI technology while enjoying the benefits of a secure and user-friendly wallet. With rewards of $50,000 worth of DA tokens, the initiative encourages users to explore Web3 in an innovative and incentivized environment. DeAgentAI and OKX Wallet aim to foster adoption and empower users in the rapidly evolving crypto space.About DeAgentAIDeAgentAI is a trailblazer in Web3 technology, introducing the first AI feedback mechanism incentive protocol that achieves "proof of insight" by integrating user feedback into the model training process. Its flagship product, AlphaX, combines advanced MOE and Transformer architectures to predict BTC and ETH price trends with over 80% accuracy.What is OKX's Web3 Wallet?OKX Wallet complements this innovation with its secure and user-friendly interface tailored for decentralized finance (DeFi) and Web3 applications. As a leading wallet in the crypto space, OKX Wallet enables seamless integration with platforms like DeAgentAI, empowering users to engage in token giveaways, explore cutting-edge AI tools, and participate in the rapidly growing Web3 ecosystem.Contact InformationYves-Alexandre d'OuradouFounderdeagent.ai@gmail.com(001) 2024989991Source: DeAgentAI Copyright 2024 ACN Newswire via SeaPRwire.com.

SAN DIEGO, CA, Dec 4, 2024 - (ACN Newswire via SeaPRwire.com) - The Japan Maritime Self-Defense Force (JMSDF) has selected the General Atomics Aeronautical Systems, Inc. (GA-ASI) SeaGuardian® Remotely Piloted Aircraft (RPA) systems for its Long Endurance Unmanned Aerial Vehicle program. This follows JMSDF use of SeaGuardian since May 2023 as part of its Medium-Altitude, Long Endurance (MALE) RPA System Trial Operations Project.SeaGuardian has been used by JMSDF to conduct various tests including whether unmanned aircraft can supplant some of the missions currently accomplished with manned aircraft. SeaGuardian is a MALE RPA system that can fly for 24 hours or more, depending on the configuration.GA-ASI has strengthened its Maritime Wide Area Surveillance (MWAS) for Japan with Optix+, which gathers information from the SeaGuardian sensors, as well as other data sources, displaying the full picture of surveillance information for its operator. This functionality makes it easy to task and direct its Intelligence, Surveillance and Reconnaissance (ISR) information in real time. GA-ASI's Optix+ software suite rapidly correlates and exploits collected data into an easily shared common operational picture. Having multi-source correlated data enables automatic detection of anomalous behaviors over waters.SeaGuardian features two multi-mode maritime surface-search radars with an Inverse Synthetic Aperture Radar (ISAR) imaging mode, an Automatic Identification System (AIS) receiver, and a High-Definition - Full-Motion Video sensor equipped with optical and infrared cameras as well as electronic intelligence receivers. This sensor suite enables real-time detection and identification of surface vessels over thousands of square nautical miles and provides automatic tracking of maritime targets and correlation of AIS transmitters with radar and electronic intelligence tracks.About GA-ASIGeneral Atomics Aeronautical Systems, Inc. (GA-ASI), an affiliate of General Atomics, is a leading designer and manufacturer of proven, reliable RPA systems, radars, and electro-optic and related mission systems, including the Predator® RPA series and the Lynx® Multi-mode Radar. With more than eight million flight hours, GA-ASI provides long-endurance, mission-capable aircraft with integrated sensor and data link systems required to deliver persistent situational awareness. The company also produces a variety of sensor control/image analysis software, offers pilot training and support services, and develops meta-material antennas.For more information, visit www.ga-asi.com .Avenger, Lynx, Predator, Reaper, SeaGuardian, and SkyGuardian are registered trademarks of General Atomics Aeronautical Systems, Inc.Contact InformationGA-ASI Media Relationsasi-mediarelations@ga-asi.comSource: General Atomics Aeronautical Systems, Inc. Copyright 2024 ACN Newswire via SeaPRwire.com.