Month: 2024-11

TOKYO, Nov 15, 2024 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. and Biogen Inc. announced today a positive opinion has been received from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending approval of the amyloid-beta (Aβ) monoclonal antibody lecanemab as a treatment of adult patients with a clinical diagnosis ofmild cognitive impairment and mild dementia due to Alzheimer’s disease (Early Alzheimer’s disease) who are apolipoprotein E ε4 (ApoE ε4)* non-carriers or heterozygotes with confirmed amyloid pathology.1 Eisai had requested a re- examination of the prior negative opinion adopted by the CHMP in July 2024. In accordance with European Medicines Agency regulatory process,the European Commission is expected to make a final decision on the marketing authorization application (MAA) of lecanemab based on the CHMP recommendation within 67 days of receipt of CHMP opinion.2Lecanemab selectively binds to soluble Aβ aggregates (protofibrils**), as well as insoluble Aβ aggregates (fibrils) which are a major component of Aβ plaques in AD, thereby reducing both Aβ protofibrils and Aβ plaques in the brain.3,4,5AD currently affects an estimated 6.9 million people in Europe,6 and this figure is expected to nearly double by 2050 as agingpopulations increase.7 AD progresses in stages that increase in severity over time, and each stage of the disease presentsdifferent challenges for those living with AD and their care partners. There is a significant unmet need for new treatment options that slow down the progression of early AD and reduce the overall burden on people affected by AD and society.Eisai serves as the lead for lecanemab’s development and regulatory submissions globally with both Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision- making authority.* Apolipoprotein E is a protein involved in the metabolism of fats in humans. It is implicated in AD.** Protofibrils are believed to contribute to the brain injury that occurs with AD and are considered to be the most toxic form of Aβ, having a primary role in the cognitive decline of this progressive, debilitating condition.8 Protofibrils cause injury to neurons in the brain which, in turn,can negatively impact cognitive function via multiple mechanisms,8 not only increasing the development of insoluble Aβ plaques but also increasing direct damage to brain cell membranes and the connections that transmit signals between nerve cells or nerve cells and other cells. It is believed the reduction of protofibrils may slow the progression of AD by reducing damage to neurons in the brain and cognitive dysfunction.9About lecanemab (generic name, brand name: Leqembi®)Lecanemab is the result of a strategic research alliance between Eisai and BioArctic. It is a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble (protofibril) and insoluble forms of amyloid-beta (Aβ).Lecanemab’s Positive Opinion from the CHMP in the European Union was primarily based on Phase 3 data from Eisai’sglobal Clarity AD clinical trial, in which it met its primary endpoint and all key secondary endpoints with statistically significant results.1,3 Clarity AD was a Phase 3 global, placebo-controlled, double-blind, parallel-group, randomized study in1,795 patients with early AD (MCI or mild dementia due to AD, with confirmed presence of amyloid pathology), of which 1,521 were in the recommended indicated population (ApoE ε4 non-carriers or heterozygotes ). The treatment group was administered lecanemab 10 mg/kg bi-weekly, with participants allocated in a 1:1 ratio to receive either placebo or lecanemab for 18 months.1The primary endpoint was the global cognitive and functional scale, CDR-SB.1 In the Clarity AD clinical trial, treatment with lecanemab, in the recommended indicated population (ApoE ε4 non- carriers or heterozygotes), reduced clinical decline onCDR-SB by 31% at 18 months compared to placebo based on conservative control based imputation.1 The mean CDR-SB score at baseline was approximately 3.2 in both groups.1 The adjusted least-squares mean change from baseline at 18months was 1.217 with lecanemab and 1.752 with placebo (difference, −0.535; 95% confidence interval [CI], −0.778 to−0.293; P=0.00001).1 CDR-SB is a global cognitive and functional scale that measures six domains of functioning, including memory, orientation, judgement and problem solving, community affairs, home and hobbies, and personal care.10In addition, the secondary endpoint from the AD Cooperative Study-Activities of Daily Living Scale for Mild Cognitive Impairment (ADCS-MCI-ADL), which measures information provided by people caring for patients with AD, noted 33% less decline compared to placebo at 18 months.1 The adjusted mean change from baseline at 18 months in the ADCS-MCI-ADLscore was −3.873 in the lecanemab group and −5.809 in the placebo group (difference, 1.936; 95% CI, 1.029 to 2.844; P=0.00002).1 The ADCS-MCI-ADL assesses the ability of patients to function independently, including being able to dress, feed themselves and participate in community activities.In the ApoE ε4 heterozygotes or non-carriers population, the most common adverse reactions were infusion-related reaction (26%), ARIA-H (13%), headache (11%) and ARIA-E (9%).1Lecanemab has been approved in the U.S., Japan, China, South Korea, Hong Kong, Israel, the United Arab Emirates and Great Britain and is under regulatory review in 17 countries. A supplemental Biologics License Application (sBLA) for intravenous maintenance dosing was submitted to the U.S. Food and Drug Administration (FDA) in March 2024, which was accepted in June 2024. In May 2024, the rolling submission of a Biologics License Application (BLA) for maintenancedosing of a subcutaneous injection formulation, which is being developed to enhance convenience for patients, was initiated in the U.S. under Fast Track status, with the rolling submission and completed in October 2024.Since July 2020 the Phase 3 clinical study (AHEAD 3-45) for individuals with preclinical AD, meaning they are clinically normal and have intermediate or elevated levels of amyloid in their brains, is ongoing. AHEAD 3-45 is conducted as a public-private partnership between the Alzheimer's Clinical Trial Consortium that provides the infrastructure for academic clinical trials in AD and related dementias in the U.S, funded by the National Institute on Aging, part of the National Institutes of Health, Eisai and Biogen. Since January 2022, the Tau NexGen clinical study for Dominantly Inherited AD (DIAD), that is conducted by Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by Washington University School ofMedicine in St. Louis, is ongoing and includes lecanemab as the backbone anti-amyloid therapy.About the Collaboration between Eisai and Biogen for ADEisai and Biogen have been collaborating on the joint development and commercialization of AD treatments since 2014. Eisai serves as the lead of lecanemab development and regulatory submissions globally with both companies co-commercializing and co-promoting the product and Eisai having final decision-making authority.About the Collaboration between Eisai and BioArctic for ADSince 2005, Eisai and BioArctic have had a long-term collaboration regarding the development and commercialization of ADtreatments. Eisai obtained the global rights to study, develop, manufacture and market lecanemab for the treatment of AD pursuant to an agreement with BioArctic in December 2007. The development and commercialization agreement on the antibody lecanemab back-up was signed in May 2015.About Eisai Co., Ltd.Eisai's Corporate Concept is "to give first thought to patients and people in the daily living domain, and to increase thebenefits that health care provides." Under this Concept (also known as human health care (hhc) Concept), we aim toeffectively achieve social good in the form of relieving anxiety over health and reducing health disparities. With a global network of R&D facilities, manufacturing sites and marketing subsidiaries, we strive to create and deliver innovative products to target diseases with high unmet medical needs, with a particular focus in our strategic areas of Neurology and Oncology.In addition, we demonstrate our commitment to the elimination of neglected tropical diseases (NTDs), which is a target (3.3) of the United Nations Sustainable Development Goals (SDGs), by working on various activities together with global partners.For more information about Eisai, please visit www.eisai.com (for global headquarters: Eisai Co., Ltd.), and connect with us on X, LinkedIn and Facebook. The website and social media channels are intended for audiences outside of the UK and Europe. For audiences based in the UK and Europe, please visit www.eisai.eu and Eisai EMEA LinkedIn.About BiogenFounded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patient’s lives and to create value for shareholders and our communities. We apply deep understanding ofhuman biology and leverage different modalities to advance first-in-class treatments or therapies that deliver superior outcomes. Our approach is to take bold risks, balanced with return on investment to deliver long-term growth.The company routinely posts information that may be important to investors on its website at www.biogen.com.Follow Biogen on social media – Facebook, LinkedIn, X, YouTube.Biogen Safe HarborThis news release contains forward-looking statements, including about the potential clinical effects of lecanemab; the potential benefits, safety and efficacy of lecanemab; potential regulatory discussions, submissions and approvals and the timing thereof; the treatment of Alzheimer's disease; the anticipated benefits and potential of Biogen's collaboration arrangements with Eisai; the potential of Biogen's commercial business and pipeline programs, including lecanemab; and risks and uncertainties associated with drug development and commercialization. These statements may be identified by words such as "aim," "anticipate," "believe," "could," "estimate," "expect," "forecast," "intend," "may," "plan," "possible," "potential," "will," "would" and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small number of research and development programs result in commercialization of a product. Results in early-stage clinical studies may not be indicative of full results or results from later stage or larger scale clinical studies and do not ensure regulatory approval. You should not place undue reliance on these statements.These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected insuch statements, including without limitation unexpected concerns that may arise from additional data, analysis or results obtained during clinical studies; the occurrence of adverse safety events; risks of unexpected costs or delays; the risk of other unexpected hurdles; regulatory submissions may take longer or be more difficult to complete than expected;regulatory authorities may require additional information or further studies, or may fail or refuse to approve or may delayapproval of Biogen's drug candidates, including lecanemab; actual timing and content of submissions to and decisions madeby the regulatory authorities regarding lecanemab; uncertainty of success in the development and potentialcommercialization of lecanemab; failure to protect and enforce Biogen's data, intellectual property and other proprietaryrights and uncertainties relating to intellectual property claims and challenges; product liability claims; and third party collaboration risks, results of operations and financial condition. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from Biogen's expectations in any forward-looking statement. Investors should considerthis cautionary statement as well as the risk factors identified in Biogen's most recent annual or quarterly report and in otherreports Biogen has filed with the U.S. Securities and Exchange Commission. These statements speak only as of the date of this news release. Biogen does not undertake any obligation to publicly update any forward-looking statements.References:1) Committee for Medicinal Products for Human Use. 2024. Leqembi (Lecanemab). Overview. Last accessed: November 2024(2) European Medicines Agency. The Centralised Procedure at the EMA. Available at: https://www.ema.europa.eu/en/about-us/what-we-do/authorisation-medicines. Last accessed: November 2024.(3) van Dyck, H., et al. Lecanemab in Early Alzheimer’s Disease. New England Journal of Medicine. 2023;388:9-21. https://www.nejm.org/doi/full/10.1056/NEJMoa2212948.(4) AlzForum. 2021. Lecanemab Sweeps Up Toxic Aβ Protofibrils, Catches Eyes of Trialists. Available at: https://www.alzforum.org/news/conference-coverage/lecanemab-sweeps-toxic-av-protofibrils- catches-eyes-trialists. Last accessed: February 2024.(5) Sehlin D, Englund H, Simu B, Karlsson M, Ingelsson M, Nikolajeff F, Lannfelt L, Pettersson FE. Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation. PLoS One. 2012;7(2):e32014.https://doi.org/10.1371/journal.pone.0032014 Epub 2012 Feb 15. PMID: 22355408; PMCID: PMC3280222.(6) Gustavsson, A., et al. Global estimates on the number of persons across the Alzheimer's disease continuum. Alzheimer’s & Dementia. 2023;19:658-670. https://alz- journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.12694.(7) Alzheimer Europe. Prevalence of dementia in Europe. Available at: https://www.alzheimer-europe.org/dementia/prevalence-dementia-europe.(8) Amin L, Harris DA. Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers. Nat Commun. 2021;12:3451. doi:10.1038/s41467-021-23507-z(9) Ono K, Tsuji M. Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease. Int J Mol Sci. 2020;21(3):952. doi: 10.3390/ijms21030952. PMID: 32023927; PMCID: PMC7037706.(10) Morris, J.C. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414.MEDIA CONTACTSEisai Co., Ltd.Public Relations Department TEL: +81 (0)3-3817-5120Eisai Europe, Ltd.EMEA Communications Department+44 (0) 797 487 9419Emea-comms@eisai.netBiogen Inc.Jack Cox+ 1-781-464-3260public.affairs@biogen.comEisai Inc. (U.S.)Libby Holman+1-201-753-1945Libby_Holman@Eisai.comINVESTOR CONTACTSEisai Co., Ltd.Investor Relations Department TEL: +81 (0) 3-3817-5122Biogen Inc.Stephen Amato+ 1-781-464-2442IR@biogen.com Copyright 2024 JCN Newswire via SeaPRwire.com.

TOKYO, Nov 15, 2024 - (JCN Newswire via SeaPRwire.com) - Resorttrust Group and Mitsubishi Corporation ("MC") have agreed to conduct a joint study of opportunities in the medical tourism sector. Under this agreement, MC and Resorttrust Group company Advanced medical care Inc.("AMC") will evaluate the establishment of a joint venture company to facilitate medical tourism to Japan and globally promote the country's advanced medical screening technologies and healthcare services.Rapid population growth and economic development in Asia have raised awareness of lifestyle-related diseases and preventive healthcare, which has in turn driven up demand for high-precision medical screenings and treatments. Resorttrust Group and MC aim to capitalizing on this growing demand by promoting medical tourism to Japan, which is renowned for its abundant medical facilities, advanced screening technologies, and high-quality healthcare services. Our objectives are to help extend worldwide healthy life expectancy and create new economic value by leveraging both the growth of Japan's healthcare-related industries and the revitalization of its local economies.In addition to providing administrative support for its Group's medical facilities, Resorttrust's know-how extends to healthcare technologies and services, as well as hotel and other tourism operations. MC brings to the table a global network of business partners, digital-transformation (DX) capabilities, and solutions for healthcare providers. This new joint venture will combine our companies' respective expertise to accomplish the following aims:1. Strengthen overseas marketing of Japanese medical services2. Develop inbound patient referral schemes for domestic medical institutions3. Take advantage of medical-facility DX to accelerate the establishment of inbound patient acceptance systemsMC and Resorttrust Group are confident that success in these initiatives will encourage global applications of Japan's medical services. Looking further to the future, our goal is to develop businesses that are invested in the mental and physical well-being of people all over the world, including wellness-tourism services that deliver Japanese health culture and traditional culture experiences.As part of this joint study, we will conduct the following verification activities at several facilities, including Nihonbashi Muromachi Mitsui Tower Midtown Clinic and Tokyo Tower Midtown Clinic, which are operated by AMC:- Market research in Asian countries for the global expansion of Japanese medical screening technologies and healthcare services- Analysis of current challenges and enhancement measures related to inbound patient referral processes- Effectiveness evaluation of AI-powered multilingual communication tools specialized for medical services, developed in collaboration with the MC Group companies, Industry One, Inc. and MC Digital, Inc.About Resorttrust, Inc.Resorttrust Group's core business includes membership-based resort hotels and hotel restaurant operations. In 1994, the group expanded into the medical /healthcare sector by launching a membership-based comprehensive medical club. Today, the group has broadened its healthcare solutions beyond medical screenings into treatment services. The group's subsidiary, Cancer Intelligence Care Systems, Inc., is developing an accelerator-based neutron irradiation system for Boron Neutron Capture Therapy, aiming to provide cancer treatments with reduced patient burden. Additionally, Resorttrust Group provides operational support to facilities offering advanced cancer immunotherapy and stem cell treatments for conditions such as arteriosclerosis, joint pain, and frailty prevention and improvement. https://www.resorttrust.co.jp/About Advanced Medical Care Inc.Consulting for medical and health screening business, support for medical facility management, education and training of medical personnel and assistants, sales of cosmetics and supplements. https://www.amcare.co.jp/About Mitsubishi CorporationMC develops diversified businesses in a wide range of industries through its eight groups: Environmental Energy, Materials Solution, Mineral Resources, Urban Development & Infrastructure, Mobility, Food Industry, S.L.C. (Smart-Life Creation), and Power Solution. https://www.mitsubishicorp.com/ Copyright 2024 JCN Newswire via SeaPRwire.com.

News Facts:Collaboration with 12 global suppliers to calculate and exchange CO2 emissions data, using a PACT -conformant solution with global standardsFujitsu's innovative offering enables transparent and reliable data exchange for calculating product carbon footprints at both product and organizational levels, allowing for visualization and reduction of emissions across the entire supply chainInitiative conformance to global standards, including the PACT Methodology, and demonstrates interoperability with solutions from multiple international partners, showcasing Fujitsu's commitment to achieving net-zero emissions across value chains by 2040KAWASAKI, Japan, Nov 15, 2024 - (JCN Newswire via SeaPRwire.com) - Fujitsu today announced that it has started an initiative on decarbonization with global suppliers leveraging product-level data exchange on CO2 emissions. The initiative represents part of Fujitsu’s efforts to achieve net zero CO2 emissions (1) across its entire value chain (Scope 3) by 2040.To achieve these decarbonization goals, since fiscal 2024, Fujitsu has been deepening its engagement with suppliers, implementing data exchange between companies using product carbon footprint (PCFs) with actual data to visualize and reduce CO2 emissions from purchased parts and materials.The initiative leverages Fujitsu's ESG Management Platform, a solution that supports the realization of corporate ESG management by visualizing, measuring, and optimizing CO2 emission reductions. Fujitsu is working with a total of 12 global suppliers (2), including Accton Technology Corporation, KAGA FEI Co., Ltd., NEXTY Electronics Corporation, Schneider Electric, Hakuto Co., Ltd., Furukawa Electric Co., Ltd., MiTAC Holdings Corporation, Lumentum Holdings Inc. and others, to achieve PCF calculation and CO2 emissions data exchange using actual data in accordance with global standards.Fujitsu, drawing from its experience and insights as a core member in the rule-making process around PCF calculation and product-level data exchange across value chains both in Japan and internationally, is well-versed in the progress of each supplier's decarbonization efforts and industry-specific challenges.As part of this initiative, in addition to the globally standardized product-based PCF calculation methodology (3) and product-level data on CO2 emissions exchange, Fujitsu successfully implemented the world's first offering that enables organization-based PCF calculation methodology (4) and data exchange, which are more prevalent among suppliers, using actual data for social implementation.Furthermore, to address suppliers' concerns about possible leakage of confidential information (i.e., product design details) in promoting CO2 emissions data exchange between companies Fujitsu’s ESG Management Platform ensures transparency and reliability through a highly confidential decentralized data management model that limits access rights to PCF calculations and connects only PCF data via an API (Application Programming Interface).By linking the CO2 emissions of suppliers from upstream in the supply chain, the platform enables the visualization of the effects of CO2 emission reduction measures, such as the introduction of renewable energy implemented by suppliers.This makes the CO2 emission reduction efforts across the entire supply chain visible as value, which can then be reflected in CO2 emission reduction scenarios for decarbonization and simulations of the effectiveness of measures.Fujitsu will continue to support a wide range of clients, including manufacturers, by combining and analyzing non-financial data such as CO2 reduction efforts with financial data including sales data, and contribute to the realization of a decarbonized supply chain.Fujitsu will report on this initiative at the ICT×Green Seminar hosted by the Japanese Ministry of Internal Affairs and Communications at the Japan Pavilion during COP29 on November 16, 2024, and will also discuss the advanced initiatives of Japanese companies.Takeshi Ogamino, Corporate Vice President, General Manager, FITEL Products Division, Communications Solutions Division, Furukawa Electric Co., Ltd., comments:“I am truly delighted that the collaboration with Fujitsu on carbon footprint data integration has been successful. Fujitsu has provided us with guidance on data integration and solutions compliant with PACT, enabling us to integrate the carbon footprint of our communication semiconductor laser products and advance new initiatives to reduce GHG emissions across the entire value chain. Looking ahead, we will continue to contribute to further GHG emission reductions, aiming for carbon neutrality by 2050 and societal transformation, to realize a sustainable future.”Xavier Denoly, Senior Vice President, Sustainable Development, Schneider Electric, comments:“Schneider Electric is working to reach net zero CO2 emissions throughout its entire supply chain, and we are pleased to work in collaboration with Fujitsu on these challenges. To help solve issues, it is important to use global standards to facilitate cooperation across the value chain.”PCF calculation and data exchange leveraging Fujitsu‘s ESG Management PlatformThe PCF calculation method on the ESG Management Platform used for this initiative leverages the “PACT Methodology” (5) and conformant to Japan’s “Green x Digital Consortium CO2 Visualization Framework (Edition 2.0.1)” powered by Japan Electronics and Information Technology Industries Association (JEITA) (6). In terms of data integration on the ESG Management Platform, it has passed interoperability tests conducted by PACT with solutions from the Digital Sustainability Cloud (DSC) of Institute for Information Industry, III in Taiwan (7) and Evalue8 Sustainability in Australia (8), and has been certified as a PACT-conformant solution in conformance to the tech specification of the "Pathfinder Framework (Version 2.2.0)" (9) as the globally standard. Utilizing the PACT-conformant solution enables data exchange on CO2 emissions between companies across countries. Moving forward, it will be possible to smoothly implement data exchange with companies based in Europe, the United States, Taiwan, and Australia. Furthermore, this data exchange also conformant to the "Green x Digital Consortium Technical Specifications for Data Exchange (Version 2.0)"..Figure: Using the ESG Management Platform Offering from Fujitsu UvanceFuture PlansFujitsu will continue to actively engage in visualizing and implementing measures to reduce CO2 emissions in the supply chain by leveraging technologies such as data and AI, while also providing the know-how gained through practice to customers and society via its ESG Management Platform.As part of Fujitsu Uvance, Fujitsu's business model to solve societal issues, Fujitsu will contribute to the realization of a sustainable supply chain and global carbon neutrality.Fujitsu will also continue to cooperate with industry organizations including the WBCSD (10) to support efforts towards rule-making aimed at achieving net-zero CO2 emissions across the entire value chain, responding to updates in global standard specifications, and strengthening supplier engagement.(1) Net zero CO2 emissions:Balancing residual emissions with the same amount of neutralization. Fujitsu aims to reduce CO2 emissions by more than 90% from the base year of 2020 by the target year of 2040. The remaining emissions of 10% or less are planned to be removed and stored through technologies that directly capture CO2 emissions from the atmosphere and absorption through afforestation.(2) 12 global suppliers:Accton Technology Corporation: Headquartered in Hsinchu, Taiwan, Chairperson Kuo-Hsiu HuangKAGA FEI Co., Ltd.: Headquartered in Kanagawa Prefecture, Japan, Representative Director, President Takeshi TsukamotoNEXTY Electronics Corporation: Headquartered in Tokyo, Japan, Representative Director, President Yasuhiro KakiharaSchneider Electric: Headquartered in Rueil-Malmaison, France, Chief Executive Officer Olivier BlumHakuto Co., Ltd.: Headquartered in Tokyo, Japan, Representative Director, President and Chief Executive Officer Tamaki MiyashitaFurukawa Electric Co., Ltd.: Headquartered in Tokyo, Japan, President (Representative) Hideya MoridairaMiTAC Holdings Corporation: Headquartered in Taoyuan, Taiwan, Chairman Matthew MiauLumentum Holdings Inc.: Headquartered in California, United States, President and Chief Executive Officer Alan Lowe(3) Product-based PCF calculation methodology:Method of calculating PCF based on the life cycle inventory analysis of greenhouse gases for each product. Requirement in PACT under global standards.(4) Organization-based PCF calculation methodology:Method of allocating Scope 1, 2, and 3 data as an organization by delivery amount, etc., for each delivery destination. Recognized as a transitional calculation method in the "Green x Digital Consortium CO2 Visualization Framework (Edition 2.0.1)" powered by JEITA(Japan Electronics and Information Technology Industries Association) and is proposed as an extension of PACT.(5) PACT Methodology:Guidance indicating the methodology for calculating and exchanging CO2 emission data.Previously, it was called Pathfinder Framework. The PACT Methodology builds on existing frameworks and standards to provide guidance on accounting, verification, and exchange of cradle-to-gate PCFs with the aim of creating more accurate, granular, and comparable emissions data. The PACT Methodology can be accessed here, with v 3.0 of the methodology and tech specs due to be released in Q1 2025.(6) Green x Digital Consortium CO2 Visualization Framework (Edition 2.0.1):Product carbon footprint calculation rules compiled by the Green x Digital Consortium Visualization WG.(7) Institute for Information Industry, III:Headquartered in Taipei City, Taiwan, DTRI Senior Deputy Director General Hubert Wang(8) Evalue8 Sustainability:Headquartered in Canberra, Australia(9) The tech specification of the Pathfinder Framework (Version 2.2.0):International technical specification for confidential and secure data exchange of emission data between companies based on solution interoperability. Solutions conformance to this technical specification are listed as PACT-conformant solutions in the PACT online catalog.(10) World Business Council for Sustainable Development (WBCSD):Organization led by CEOs of approximately 230 global companies aiming to achieve a sustainable society through business activities, with Fujitsu serving as a board member.About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers in over 100 countries, our 124,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: Computing, Networks, AI, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.7 trillion yen (US$26 billion) for the fiscal year ended March 31, 2024 and remains the top digital services company in Japan by market share. Find out more: www.fujitsu.com.Press Contacts:Fujitsu LimitedPublic and Investor Relations DivisionInquiries Copyright 2024 JCN Newswire via SeaPRwire.com.

TOKYO, Nov 15, 2024 - (JCN Newswire via SeaPRwire.com) - TANAKA Kikinzoku Kogyo K.K. (Head office: Chuo-ku, Tokyo; Representative Director & CEO: Koichiro Tanaka), which develops industrial precious metal products as one of the core companies of TANAKA Precious Metals, announced that it has succeeded in developing the world’s first bulk2 platinum with controlled crystal grain3 size in the nano scale.The average grain size of a typical bulk metal is about 10 μm at the smallest. In this new technology, the average crystal grain size can be controlled in the nano scale. As a result, the developed pure platinum, with 99.9% or higher purity, has 10 times the hardness and 4 times the strength of typical platinum materials.It is known that the properties of metals, including precious metals, are enhanced by grain refinement. In recent years, steel and nonferrous metals with nano-sized crystal grains have been produced by deformation processing to apply extreme levels of plastic deformation5 and recrystallize their structures. While deformation processing temporarily hardens6 metal materials, when highly pure precious metal materials undergo the same process, the arrangement of atoms that form their crystalline structure changes and new crystal grains are nucleated and grown over periods of a few hours to a few days. As a result, the hardness of the material noticeably decreases (softens), and it has been very difficult to refine the crystal grains through deformation processing.TANAKA Kikinzoku Kogyo has succeeded in manufacturing bulk platinum with controlled crystal grain size in the nano scale by optimizing the manufacturing process. The hardness and strength of the platinum materials manufactured by this technology are much higher than those of typical platinum materials. The developed platinum has a high density of small-angle grain boundaries, large-angle grain boundaries, dislocations, and other lattice defects within the material. Therefore, the developed platinum has properties that are clearly different from the properties of commonly known platinum materials, even without additive elements or alloying. As a new material with high purity and high functionality, it is expected to be applied to a wide field of industries, including the electronics and aerospace industries.Material Development of Nanostructured BulkMany metal materials are polycrystalline, consisting of small crystal grains. It is considered that their properties can be improved by refinement of the crystal grains. The finer the grains, the higher the proportion of grain boundaries or lattice defects, such as dislocations, in the overall material. In materials with nanoscale grain, the ratio of lattice defects is incomparably higher than in commonly known materials, of which the physical properties and characteristics are usually discussed. As a result, unique physical properties and characteristics that are dramatically different from conventional materials are obtained.1 World’s first: As of October 30, 2024, and based on internal research (according to a survey of patents and papers on bulk platinum materials)2 Bulky, bulk: Bulky refers to the state of material where clumps of atoms within the material, not on the surface, are connected three-dimensionally. Solid matter with a bulky structure is called bulk.3 Crystal grains, crystal grain size: Metals have a structure with a regular arrangement of atoms. Crystal grains refer to individual areas of this structure where the orientation of the atomic arrangement is different from neighboring areas, and crystal grain size refers to the diameter of the grains.4 Electron backscatter diffraction (EBSD): A method of investigating information on material crystals (crystal system, grain size, orientation, etc.) by analyzing the backscatter diffraction from the surface of a material with a crystalline structure when irradiated with an electron beam5 Plastic deformation: The amount of deformation that remains in a material, without it returning to its original state, after applying an external force to the material to deform it and then removing that external force6 Work-hardened: The phenomenon of a metal being hardened by applying stress to the metal to accumulate plastic deformation7 Royal Pure Platinum: An original material manufactured by TANAKA Kikinzoku Kogyo, with higher hardness and strength than normal platinum materials while maintaining a purity of 99.9%About TANAKA Precious MetalsSince its foundation in 1885, TANAKA Precious Metals has built a portfolio of products to support a diversified range of business uses focused on precious metals. TANAKA is a leader in Japan regarding the volume of precious metals it handles. Over many years, TANAKA has manufactured and sold precious metal products for industry and provided precious metals in such forms as jewelry and assets. As precious metals specialists, all Group companies in Japan and worldwide collaborate on manufacturing, sales, and technology development to offer a full range of products and services. With 5,355 employees, the group’s consolidated net sales for the fiscal year ending December 2023, was 611.1 billion yen.Global industrial business websitehttps://tanaka-preciousmetals.com/en/Product inquiriesTANAKA Kikinzoku Kogyo K.K.https://tanaka-preciousmetals.com/en/inquiries-on-industrial-products/Press inquiriesTANAKA Holdings Co., Ltd.https://tanaka-preciousmetals.com/en/inquiries-for-media/Press release: http://www.acnnewswire.com/docs/files/20241114_EN.pdf Copyright 2024 JCN Newswire via SeaPRwire.com.